Buy Glucosamine And Chondroitin Online
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buy glucosamine and chondroitin online
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The anti-inflammatory properties of glucosamine and chondroitin suggest that they may have potential effects in cancer prevention. We performed this meta-analysis to assess the protective function of glucosamine and/or chondroitin intake against cancer risk. We searched the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) databases. The odds ratio (OR), corresponding to the 95% confidence interval (95% CI), was used to assess the association between chondroitin and/or glucosamine intake and cancer risk. Thirteen studies met the inclusion criteria, with 1,690,918 participants and 55,045 cancer cases. Overall, chondroitin and/or glucosamine intake was associated with a lower risk of colorectal cancer (OR = 0.91, 95% CI, 0.87-0.94) and lung cancer (OR = 0.84, 95% CI, 0.79-0.89). Subgroup analysis supported the protective effect of different SYSADOAs (chondroitin and/or glucosamine) intake. However, the protective effect was not observed in the only chondroitin intake group and in the NSAIDs group. Our meta-analysis found that the intake of glucosamine and/or chondroitin decreased the risk of colorectal and lung cancers. Moreover, NSAIDs use may have a synergistic protective effect.
Bio-Glucosamine+Chondroitin is a preparation consisting of light blue tablets each containing 500 mg of glucosamine sulphate corresponding to 400 mg pure glucosamine, 400 mg chondroitin sulphate, and 20 mg of vitamin C.
Description:- "Glucosamine sulfate is a naturally occurring chemical found in the human body. It is in the fluid around joints. Glucosamine also exists in other places in nature. For example, glucosamine sulfate used in dietary supplements is often obtained from the shells of shellfish. Glucosamine sulfate used in dietary supplements does not always come from natural sources. It can also be made in a laboratory.There are different forms of glucosamine including glucosamine sulfate, glucosamine hydrochloride, and N-acetyl glucosamine. These different chemicals have some similarities, but they may not have the same effects when taken as a dietary supplement. Most of the scientific research on glucosamine has involved glucosamine sulfate. See separate listings for glucosamine hydrochloride or N-acetyl glucosamine. Dietary supplements that contain glucosamine often contain additional ingredients. These additional ingredients are frequently chondroitin sulfate, methylsulfonylmethane (MSM), or shark cartilage. Some people think these combinations work better than taking just glucosamine sulfate alone. So far, researchers have found no proof that combining the additional ingredients with glucosamine adds any benefit.Glucosamine sulfate is most commonly used for osteoarthritis. It is also used for many other conditions, but there is no good scientific evidence to support these uses."
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Core tip: In this review we present and critically evaluate the current information regarding the administration of glucosamine (GL) and chondroitin (CH) for the treatment of knee or hip osteoarthritis. A clinical and radiological effect of GL and CH has been shown. However, only a few high quality trials exist. The effect sizes are small and probably not clinically relevant. The validity of these results is limited by high risk of bias introduced in the studies. Both GL and CH seem to be safe with no serious adverse events but there is currently no convincing information for their efficacy as treatment options in osteoarthritis.
Because of the publicity it has received in the media, glucosamine has become one of the most commonly used dietary supplements in the United States. Several studies sponsored by the supplement industry have suggested that glucosamine is effective in the management of osteoarthritis. A meta-analysis of early trials of this supplement discovered methodologic problems and possible publication bias, and in two recent independent trials, glucosamine therapy was found to be ineffective for osteoarthritis. Because trials of osteoarthritis treatment are burdensome and costly, McAlindon and associates developed a method for performing clinical trials using the Internet, and used this technique to evaluate the safety and effectiveness of glucosamine in the management of knee osteoarthritis.
The authors conducted a double-blind, placebo-controlled study of glucosamine in patients with osteoarthritis. The patients were recruited and followed using the Internet. Inclusion criteria were: 45 years or older; osteoarthritis of at least one knee, as established by radiography or magnetic resonance imaging; and pain, aching, or stiffness in either knee on most days. Exclusion criteria were: a knee injection within 60 days of the study; arthroplasty of the knee; and current use of glucosamine, chondroitin, or other agents that claim to have osteoarthritis structure-modifying properties. The patients were randomized to receive 1.5 g of glucosamine or placebo daily for 12 weeks. The main outcome measure was the pain subscale on the Western Ontario and McMaster Universities Osteoarthritis Index, which includes three subscales (pain, stiffness, and function) and generates scores for each subscale as well as an overall score. Analgesia use and adverse events also were recorded.
There were 205 patients enrolled in the study. The groups receiving glucosamine and placebo did not differ with regard to pain scores, stiffness, physical function, overall scores on the Index, and analgesic use. No significant differences were noted between the patients who received glucosamine and those who received placebo when the groups were stratified for severity of osteoarthritis, glucosamine product, use of a nonsteroidal anti-inflammatory drug, and the exclusion of opiate use. The groups had similar numbers and types of adverse events recorded during the study.
The authors conclude that glucosamine, while appearing to be safe, is no more effective than placebo in treating the symptoms of knee osteoarthritis. They add that Internet-based clinical trials may provide a quick and efficient method for further studies on the effectiveness of glucosamine products.
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